A key aim of the Safety in Practice programme is to reduce the harm experienced by patients from medication use. One of the medicines most commonly implicated in adverse drug events (ADEs) causing admission to hospital are non-steroidal anti-inflammatory drugs (NSAIDs) and aspirin, which are responsible for 30% of ADE hospital admissions, mainly due to bleeding, myocardial infarction (MI), stroke, and renal damage. Some of this harm is unavoidable. High risk NSAID prescribing is common and varies about four-fold between practices. This module focuses on high-risk use of NSAIDs.